![]() ![]() infusions over 10 min) for up to 3 h following RORR. infusion over 10 min), and dexmedetomidine (20 and 35 μg/kg I.V. Cognitive recovery trajectories were assessed after isoflurane (2% for 1 h), sevoflurane (3% for 20 min), propofol (10 mg/kg I.V. During each session we tracked both the proportion of correct (accuracy) and missed (omissions) responses over time. ![]() Rats are rewarded with food pellets for selecting the correct window within the time limit. In the 5-CSRTT, rats learn to attend to a five-windowed touchscreen for the presentation of a stimulus. Here we use an operant conditioning task, the 5-choice serial reaction time task (5-CSRTT), to measure sustained attention, working memory, and inhibitory control in male and female rats as they recover from the effects of several different clinical anesthetics. However, tracking the recovery of cognitive function is comparatively difficult. In rodents, levels of consciousness are traditionally captured by physiological responses such as the return of righting reflex (RORR). ![]()
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